Tranexamic Acid
C₈H₁₅NO₂
Powerful Pigmentation Fighter for Brighter, Even-Toned Skin
What Is Tranexamic Acid?
Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine, originally used in medicine to reduce blood clotting. In skincare, it’s celebrated for its ability to tackle stubborn hyperpigmentation, including melasma, sunspots, and post-inflammatory marks (like acne scars).
How It Works
- Blocks Melanin Pathways:
Inhibits plasminogen activation, which reduces the production of prostaglandins and melanocyte-stimulating hormones (MSH) that trigger melanin synthesis. - Anti-Inflammatory: Calms redness and irritation, making it ideal for sensitive or acne-prone skin.
- Safe for Long-Term Use: Unlike hydroquinone, it’s non-cytotoxic and suitable for extended treatment.
Key Benefits
- Fades Dark Spots: Targets melasma, sun damage, and acne scars.
- Reduces Redness: Helps with rosacea and post-inflammatory erythema (PIE).
- Gentle & Versatile: Works on all skin types, including sensitive skin.
How to Use in Skincare
- Concentration:
- 2–5% in serums, creams, or spot treatments (e.g., SkinCeuticals Discoloration Defense).
- Layering:
- Pairs well with niacinamide (brightening), vitamin C (antioxidant boost), and SPF 30+ (mandatory for UV protection).
- Avoid combining with strong acids (e.g., glycolic/lactic) in the same routine to prevent irritation.
- Results: Visible improvement in 8–12 weeks with consistent use.